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doi: 10.3389/fimmu.2022.986847 Received 05 July 2022 Accepted 08 September 2022 Published 23 September 2022 Volume 13 - 2022 Edited by Keiji Hirota, Kyoto University, Japan Reviewed by Michihito Kono, Hokkaido University, Japan

Furthermore, a number of recent studies underscore that EVs are involved in redox metabolism

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Free Radic Biol Med (2001) 30(11):1191212.10.1016/S0891-5849(01)00480-4 29 WattersJLSatiaJAda CostaKABoysenGCollinsLBMorrowJDet alComparison of three oxidative stress biomarkers in a sample of healthy adults

Conversely, Esm1 + ECs, Arterial EC1 and Arterial EC2 exhibit higher expression of arterial markers but low transcript levels for cell cycle genes, confirming previous observations 4,14,15,34,35,45