Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-MMAE Size:1mg and perhaps most importantly

and perhaps most importantly

It can also be reversibly coupled to aldehydes and ketones to form a Schiff base - which can be reduced to a generate stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3)

such as genome duplication and chromatin maintenance

making the linkers highly adaptable for diverse ADC and related applications

Product Name Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C56H94N8O21 Molecular Weight 1215

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-MMAE Size:1mg and perhaps most importantlySOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly