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Paradoxically, just after toxicity onset, there may be brief hypertension or fast heart rate, followed by severe hypotension

Dietary pectin shortens the biologic half-life of vitamin B-12 in rats by increasing fecal and urinary losses

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These changes were characterized by either an increase in muscle size and density or a reduction in fat content

Moreover, for further details on which vitamin B12 active ingredient to choose, see our article: Vitamin B12 Forms Vitamin B12 Overdose Since vitamin B12 is considered harmless and hardly any negative side effects of an overdose of the vitamin are known, some experts recommend playing it safe when it comes to B12

For long-term storage beyond 30 days, re-lyophilization is ideal but impractical without laboratory equipment