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Next, we step-wisely removed potential pleiotropic SNPs from the above PRSs to obtain the valid-PRSs, again based on a pre-defined set of P -value thresholds for the exploratory GWAS (i.e., 0.05, 0.1, 0.2, 0.3, 0.4, and 0.5)

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[15] Smoking just one cigarette a day results in a risk of coronary heart disease that is halfway between that of a heavy smoker and a non-smoker