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In non-small cell lung cancer, NRF2 upregulates the expression of PHGDH, PSAT1 and SHMT2 by activating ATF4, thereby driving SSP activation, which is associated with poor clinical prognosis (101)

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This analytical approach can integrate data from different regions and populations, identify the main drivers of disease and mortality, and forecast future trends (13, 14)

In phase 3 trials, lecanemab and donanemab slowed clinical decline in early Alzheimers by roughly a quarter to a third over eighteen months, with a known risk of amyloid-related brain swelling and small bleeds

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