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However, ACSL4 is not necessary for all ferroptotic cell death, which means under special circumstances ferroptosis is able to be induced in ACSL4-depleted cells ( Ferroptosis is induced due to lipid peroxidation activated via non-enzyme-dependent (Fenton reaction) and enzyme-dependent processes

This is when there is a similar protein sequence on the pathogen to that of human tissue

Meng Y, Wang K, Wang T, Tu Y, Gong S, Zhang Y, Zhang G, Au W, Christiani DC, Xia Z-L (2021) Early occupational exposure to lead on neutrophil-to-lymphocyte ratio and genotoxicity

doi: 10.1111/j.1750-3841.2010.01890.x

[1] These mechanisms lead to reduced caloric intake and significant weight loss, with clinical trials demonstrating average weight reductions of 15-21% over 72 weeks in the SURMOUNT-1 trial

To be included in the randomised controlled trial analysis, studies had to have a control group for both the treatment and the post-treatment follow-up period