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Similar associations have been reported in bipolar disorder and systemic lupus erythematosus, where individuals with severe BBB disruption had more extensive brain volume loss or greater psychiatric morbidity 50,51

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Epitalon has also been studied for its role in regulating circadian rhythms

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3c), displacing lipid molecules and inducing curvature, which is essential for curvature-driven protein assembly 42

Normalized debutyrylation efficiencies of Sirt13, Sirt6, and Sirt7 and normalized demalonylation efficiencies of Sirt5 are shown in Fig