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Acknowledgements The authors are thankful to the Department of Biotechnology, Ministry of Science & Technology, Government of India for the Bioinformatics infrastructure facility at Jamia Hamdard under the BTISNet program

This is particularly noteworthy because two competing oral small-molecule GLP-1 programs from Pfizer, lotiglipron (discontinued in 2023) and danuglipron (discontinued in April 2025), were terminated due to liver toxicity concerns