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During normal hematopoiesis, AIFM2 expression is low in HSCs and CMP and high in mature myeloid cells such as PMN and monocytes

Blood 2017;129:2429-36

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doi: 10.1016/j.apjr.2016.01.006 104 KamalDAMSalamtNYusufANMKashimMIAMMokhtarMH

In T cells, inhibition of mTOR activity may lead to compromised activation of c-MYC signaling pathway, causing metabolic stress and affecting T cell proliferation [158]