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Diabetic hyperglycemia further exacerbates this by suppressing astrocytic pentose phosphate pathway flux, which depletes nicotinamide adenine dinucleotide phosphate (NADPH) reserves [132, 133], a mechanism that mirrors defects in diabetic neuropathy where impaired redox defense amplifies oxidative injury

Adding insult to injury: Cochlear nerve degeneration after temporary noise-induced hearing loss

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Thus, the source of data for transfer rates and its limitations also have to be considered

20 Indeed, as one expert recently put it, maybe its time to make this long story short about metformin: It works to prevent cancer