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Baik SH, Kang S, Lee W, Choi H, Chung S, Kim JI, et al

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Most of the foundational studies are animal models, with a growing body of clinical observation and anecdotal reporting from practitioners and patients

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It is believed that it is the decreased methylation of CpG regions (locales within the DNA of the T cells with a cytosine base adjacent to a guanine base) that results in the shift from regulatory TH1 cells to the more indiscriminate and reactive TH2 cells

Underlying Health Conditions: Conditions like pernicious anemia, Crohns disease, or celiac disease can affect B12 absorption and necessitate ongoing treatment