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Researched applications The published preclinical literature documents the effects of BPC-157 in the following areas (mostly in animal models): Tendon and ligament healing , Achilles tendon, medial collateral ligament (MCL, the ligament on the inner side of the knee), tendinopathy models Muscle injuries , quadriceps (front thigh), gastrocnemius (calf muscle), transections and contusions Bone and joint healing , osteoarthritis models, fracture healing, periodontal tissues (around the teeth) Gastrointestinal diseases , gastric lesions caused by alcohol or NSAIDs (ibuprofen, diclofenac), colitis, IBD models (Crohns disease), fistulas Hepatoprotection , protection of the liver against toxic damage (paracetamol overdose, CCl, alcohol) Vascular healing , endothelial dysfunction, thromboses, healing of vascular anastomoses after surgery, thrombocytopenia (low platelet count) Skin wounds , acute as well as diabetic wounds, burns Nerve regeneration , peripheral (sciatic nerve crush) as well as central (cerebral ischemia models, i.e

However, compared with its extensive laboratory literature, human clinical evidence remains limited

Hepatitis B virus (HBV) infection is one of the most common causes of chronic viral hepatitis, especially in developing countries

Long-term effects of sustained growth hormone signaling also connect to improved glucose metabolism in certain individuals, which can decrease risk factors for type 2 diabetes and promote cardiovascular health

2016;137(4):e20151784

doi: 10.1038/s41564-019-0371-3 101 XieJLiYShenXGohGZhuYCuiJet al