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The peptide was synthesized using solid-phase methods and purified via reverse-phase high-performance liquid chromatography (HPLC)

From its rhizome the active principles such as curcuminoids are obtained, among which, the most active is represented by curcumin

A central objective of pro-oxidant therapeutic strategies is to trigger ferroptosis a distinct, iron-dependent form of regulated cell death characterized by excessive lipid peroxidation

The use of lipid particles, i.e., liposomes, with a surface coating of hydrophilic polymer chains, such as polyethylene glycol (PEG) chains, for targeting has been proposed (Allen, et al., Biochimica et Biophysica Acta 1237: 99-108 (1995)