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The answer depends on timing

There's a lot of debate nowadays about whether or not you should emphasize cold or whether or not you should emphasize heat

In sum, given the central importance of chaperones in protein homeostasis, or proteostasis, they may serve as rational targets for the design of therapeutic strategies in neurodegenerative diseases associated with aberrant protein folding including PD

Neural stem cells of the subventricular zone contribute to neuroprotection of the corpus callosum after cuprizone-induced demyelination

Human clinical trials are limited, and regulatory status varies by jurisdiction

Sadly, the expiry was the end of April 2021, so perhaps they're too far gone now