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Pigmentation manifests as dark brown to black in color, can intensify with age, and is influenced by systemic therapies, smoking, and hormones [19,20]

The alpha toxin is the most toxic enzyme that is produced by the A strain, and is also a crucial virulence factor

Lekalakala PT, Khammissa RA, Kramer B, Ayo-Yusuf OA, Lemmer J, Feller L

As extensive loss of tissues may potentially influence the feasibility of further surgical interventions, such as the sentinel lymph node biopsy, the use of proper biopsy techniques is essential during the primary treatment of melanoma

doi: 10.1097/PAS.0b013e3181cf7fa0 5 HarbstKStaafJLaussMKarlssonAMsbckAJohanssonIet al

Cancer 1999 Oct 1;86(7):1285-1293