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If the patient declines buprenorphine or methadone therapy, then they may be treated with shorter-acting full opioid agonists to prevent withdrawal (e.g., IV morphine or oral morphine IR as needed)

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Exercise tolerance*

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These include cardiovascular responses (tachycardia, palpitations, elevated blood pressure), central nervous system symptoms (insomnia, restlessness, jitteriness, dizziness, tremors, headache), mood changes (euphoria or irritability), and gastrointestinal effects (dry mouth, unpleasant taste, constipation, occasional diarrhea)

Traumatic Brain Injury Support: There is ongoing research into whether Dihexa could aid in the recovery of cognitive function following injuries, though more rigorous human data is needed