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Theranostics 7 , 3653 (2017)

In humans, a systematic review and meta-analysis revealed that physiologically high selenium levels in the body were negatively associated with cardiovascular disease morbidity and mortality

The results showed that CRC DTP cells exhibited reduced sensitivity to the modeling drugs, and were reversible, quiescent, and specifically sensitive to ferroptosis induced by GPX4 inhibitors due to the upregulated GPX4 and ferrous iron