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In turn, this may increase risk of atherosclerosis, cardiovascular disease, insulin resistance, and Type 2 diabetes

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The compound's interaction with nitric oxide pathways governs vascular tone in joint tissue, improving blood flow and reducing localized swelling

Together, these roles make B-12 essential for sharp thinking, memory, and mental energy, Fotuhi said

If you experience persistent or severe side effects, your prescriber may recommend slowing the dose escalation, dropping back to a lower dose temporarily, or trying a formulation with additives like glycine and B12 that can help reduce gastrointestinal symptoms