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Effects of estrogen on the human pituitary: a clinicopathologic study

10.1111/iju.13985 29 BiswasR.BagchiA

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, characterized by an excessive hepatic fat accumulation in the absence of alcoholic abuse, steatogenic medications or others concomitant liver diseases (2)

Recently has shown increasing frequency

C3a and C5a are critical immunomodulators that, in addition to serving as anaphylatoxins, also function as potent immunomodulatory agents through their cognate receptors (C3aR, C5aR1, and C5aR2 or C5L2), which are expressed on various innate and adaptive immune cells

HA and IR can exacerbate endothelial damage and disrupt endothelium-dependent vasodilation mechanisms, leading to vascular smooth muscle hypertrophy and lipid metabolism disorders (Krentowska and Kowalska, 2022