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Following RP-HPLC purification, a 20-mM solution of each macrocycle in DMSO was treated with 0.2 M of NHS-fluorescein, NHS-biotin or NHS-PEO4-biotin, and then purified by RP-HPLC

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For more intensive support, up to 2 capsules of each may be taken per day (morning and evening split)

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But there was none of the edge I get with caffeine