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Moreover, ATF4 knockdown in T315I-Bcr-Abl cells also slowed down DNA replication fork progression (Fig

IS is approximately 90% bound to albumin in blood circulation and is primarily secreted and excreted through organic anion transporters (OAT1 and OAT3) in renal proximal tubules (113)

Acta Pharmacol Sin 43:529540

More recently this view has been challenged by the discovery of several regulated non-apoptotic cell death pathways activated in specific disease states, including poly(ADP-ribose) polymerase-1 (PARP-1) and apoptosis inducing factor 1 (AIF1)-dependent parthanatos, caspase-1- dependent pyroptosis and receptor interacting protein kinase 1 (RIPK1)-dependent necroptosis (Bergsbaken et al., 2009

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