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530 In a randomized controlled trial, 160 sedentary men and women over age 55 who had cognitive impairment but no dementia, and cardiovascular risk factors, undertook either aerobic exercise, a DASH diet, both, or a health education program

"Ethical recommendations for cephalopod embryo experimentation in scientific research" for ethical recommendations)

Nuclear IGF-IR can not only bind to IGF-IR promoter DNA and promotes the transcription of itself [85], but also directly binds DNA and recruit RNA polymerase II to upregulate JUN and FAM21 expression in cancer cells [86]

Therefore, this study is pioneering in evaluating the brain targeting of BER through intranasal delivery of chitosomes via the olfactory mucosa for PD management

4 Limitations and countermeasures of curcumin in clinical application 4.1 Limitations of curcumin application However, the application of curcumin is limited by its physicochemical properties, particularly its low water solubility and poor intestinal permeability

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