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Front Vet Sci

BMSCs modulate the CD40/CD40L pathway to influence iron homeostasis and lanosterol synthesis in MM cells, driving ROS accumulation and ferroptosis ( A recent study revealed that mitochondrial metabolic kinase PCK2 phosphorylates and activates ACSL4, driving phospholipid remodeling linked to ferroptosis

The pathogenesis of LDDD involves age-related (Ohnishi et al., 2018) or injury-induced (Wang et al., 2023) degeneration of the intervertebral discs (IVDs)