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It is sporadic because most cases are recessive and two defective Apolipoprotein E (ApoE) alleles (ApoE 2/2) are required, plus additional environmental factors are necessary for full expression of the dyslipidemia

Concurrently, altered glucose metabolism in the orbitofrontal cortex and limbic regions reflects energy deficits and mitochondrial dysfunction, contributing to the severity of psychiatric symptoms, such as paranoia, agitation, and mood disturbances ( MRI studies have further identified gray matter atrophy in the prefrontal cortex, medial cingulate gyrus, and hippocampus, regions that are critically involved in memory, decision-making, and emotional regulation (Thompson et al., 2004)

Chitwood BG, Chitwood MB: Introduction to Nematology

Prostate cancer foundation white paper on combination therapy for metastatic hormone-sensitive prostate cancer

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