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The hemolysis-derived heme could initiate inflammatory OxS that may cause microvascular thrombosis, organ ischemia and MODS in severe COVID-19 102,105

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Moreover, we found that patient 27s T cell proliferation was uniquely responsive to these ROS-lowering drugs (Figure 5D)

Sanguinarine reduces the expression of GPX4 and increases the expression of ACSL4, thereby inducing the ferroptosis of RCC cells (181)

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