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Animal studies show that sleep deprivation enhances the expression of IL-1 and TNF- mRNA in brain regions involved in sleep regulation, including the frontal cortex, hypothalamus, hippocampus, basal forebrain, and pons in rodents [4, 9,10,11]

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The therapeutic ingredient in Coleus forskohlii is found in its root, which was used originally in a paste form for treating a variety of disorders including cardiovascular conditions because of its vasodilating effect

These mechanisms collectively help cells manage oxidative stress, maintain redox balance, and protect against oxidative damage

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This suggests that targeting TET2 could be a dual weapon strategy to both improve CAR-T cell therapy outcomes and simultaneously reprogram MDSCs to weaken their suppressive influence within the TME