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KEGG and GO functional enrichment analysis To further examine the molecular function of the identified DEGs, KEGG pathway analysis indicated that the most prevalent pathways influenced by dietary WE across multiple tissues in the ZDF rats were: glutathione metabolism

& van Laarhoven, C

Ghaseminejad, A., Ghaderi, A., Ghotloo, S., Akbari, H., et

Furthermore, several preclinical studies have shown that metformin in combination with PD-1 inhibitors inhibits the growth of cancer cells in mouse models of different tumor types and leads to a significant increase in the number of tumor-infiltrating CD8 + T cells [397, 398]