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During the resolution of inflammation, SPMs produced by polymorphonuclear cells and macrophages act to limit local tissue damage caused by inflammatory responses, including signaling cessation of polymorphonuclear cell infiltration, macrophage switching to an anti-inflammatory phenotype, apoptotic cell clearance, and reducing pain caused by nociceptor sensitization (61)

This process supports overall antioxidant capacity

Understanding your body's stress response can inform lifestyle modifications and therapeutic interventions to optimize adrenal function

Dolovich MB, Dhand R

Thus, determining whether metabolic changes observed in vivo are the either the cause or the result of a toxicity event, represents a significant challenge in metabolomics ( On the other hand, in vitro metabolomics can overcome the limitations of in vivo studies and reveal early events following drug exposure