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Systematic review and meta-analysis of randomized placebo-controlled trials of folate and vitamin B12 for depression International Psychogeriatrics (2015), DOI: 10.1017/S1041610215000046 9

Three important characteristics of the P-450 system have roles in drug-induced toxicity: 1

All these changes lead to cytokine storm characterized by increased expression and release of proinflammatory cytokines that participate in the pathogenesis of ARDS during virus respiratory infections like COVID-19

In individuals with defective glucuronidation SN-38 accumulates and elicits neutropenia and diarrhea

In the presence of inflammation, neutrophil apoptosis is delayed by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and granulocyte macrophage colony-stimulating factor (GM-CSF)