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The weaker binding and lower occupancy levels (~20%) of BV in Ab DPcob suggest that evolutionary pressures may have reduced the requirement for BV and resulted in a different role for the globin-like domain in these more complex fusion proteins

The Journal of Chemical Physics

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TRPM4 knockdown substantially reduced cellular inflammation, oxidative stress, and lipid peroxidation, thereby improving endothelial function and potentially modulating atherosclerosis progression

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Discussion The control of Cys reactivity is of paramount importance in chemical biology research owing to the frequent use of its thiol functionality for protein synthesis as discussed in this work, but also for the site-specific modification of peptides or proteins