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While there was no significant difference in overall ALS functional rating scores (ALSFRS-R) between the groups after treatment, post-hoc analysis revealed that subjects in earlier stages of the disease showed a greater treatment effect (Edaravone [MCI-186] ALS 16 Study Group 2017)

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48 JAK/STAT signaling pathway The janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway is involved in cell proliferation, differentiation, apoptosis, and inflammation response

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Treatment with P28GST, a schistosome-derived enzyme, after acute colitis induction in mice: decrease of intestinal inflammation associated with a down regulation of Th1/Th17 responses