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Although the reaction of albumin thiols with oxidants is not particularly fast, the plasma concentrations of albumin are so high, especially considering the limited number of antioxidant enzymes available in the body (42), that Cys-34 provides ~80% of the free thiols groups in plasma (4345), while the free thiol groups in plasma usually act as the main scavengers of various oxidants (46)

2026 Jun 15;40(11):e72010

A.CranswickN

Linking pathogenic mechanisms of alcoholic liver disease with clinical phenotypes

Moderate IGF-1 elevation: Clinical studies show that these compounds produce modest, stable increases in IGF-1, generally remaining within normal limits for age

GSK-3 phosporylates Nrf2 which leads to its ubiquitination and subsequent degradation, thus when GSK-3 is inactived Nrf2 is upregulated and leads to higher expression of antioxidative enzymes [99]