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Furthermore, they defend against infections by generating antimicrobial metabolites, modifying toxins or pathogen receptors, and activating distinct immune responses to pathogens (Pardo-Est et al., 2024)

EGCG is hydrolysed into smaller molecules and converted into epigallocatechin (EGC), EGCG, and EC (Jayabalan et al., 2008)

Acknowledgements We would like to acknowledge the biorender (biorender.com) and figdraw (figdraw.com) for providing assistance in figure drawing

The exact etiopathogenesis is still unknown, and it has been associated with multiple factors such as: oxidative stress, ultraviolet radiation, genetic factors, and lifestyle factors such as smoking, nutritional and emotional factors

b , Quantification of BrdU + cells per crypt (n = 40), OLFM4 + crypt length (n = 14), and LYZ + Paneth cells per crypt (n = 40) from 5 control and 5 CysRD diets treated mice under homeostasis condition

Curcumin piperidone derivatives induce caspase-dependent apoptosis and suppress miRNA-21 expression in LN-18 human glioblastoma cells