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On the prohibition side, Bhutans decade-long sales ban (201021) offers a cautionary tale: despite a strict ban and high taxes on imports, smuggling became rampant and tobacco use barely fell (prevalence ~25% before and after)

p 0.05), and the relationship between smoke exposure and constipation remained relatively stable in across all subgroups

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Excessive drinking has been implicated in the formation of at least 60 major types of disease, and more than 2.5 million people die every year because of it

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