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Additionally, the cell membrane becomes fragmented and develops blebbing, although the nucleus remains largely unchanged in appearance (126)

These modifications can lead to mutations, genomic instability, and if not adequately repaired, contribute to carcinogenesis and other genetic disorders [39]

In summary, while small observational uses of alpha-lipoic acid in pregnancy have not reported acute problems, the absence of comprehensive safety data means ALA is not routinely recommended for pregnant or lactating women

The cells were sonicated for 10 min

Ni B, Liu Y, Gao X, Cai M, Fu J, Yin X et al (2022) Isoliquiritigenin attenuates emodin-induced hepatotoxicity in vivo and in vitro through Nrf2 pathway