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Reference: Kleinman HK & Sosne G (2012)

Others cause a cascading effect that damages nerves

Luminal A tumors are generally associated with a more favorable prognosis and typically express ER and PR

Absorption problems Even with adequate intake, absorption can be reduced by: Certain gastrointestinal conditions affecting the stomach or small intestine Some medications Age-related reduction in stomach acid (which can affect absorption) Autoimmune gastritis (often historically referred to as pernicious anaemia) This is a well-recognised cause of B12 deficiency and may require ongoing management