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Based on available evidence, the American Thoracic Society recommends augmentation therapy for individuals with both a documented severe deficiency of alpha 1-antitrypsin and fixed airflow obstruction

The plasma redox state and ageing

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[54] was cited in the Alternative Medicine Review (not PubMed indexed) in 2002 [58], and APAP was listed by the author as a potentially neurotoxic compound in children with oxidative stress

Immunostained slides were independently reviewed by senior pathologists (5 years experience) at the Department of Pathology, Fujian Medical University Union Hospital, who were blinded to all clinical information

Mitochondrial dysfunction, glutathione depletion, and inhibition of antioxidant enzymes such as superoxide dismutase (SOD) and catalase lead to ROS accumulation and oxidative DNA damage