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One double-blind, placebo-controlled RCT by investigated the use of ALC for the treatment of established CIPN (grade 2 or 3, NCI-CTC v3.0) in 240 patients with various solid tumours

Skin health and anti-aging: weak evidence Research on ALA for skin health is limited, with most findings coming from in vitro and animal studies.33 34 These suggest that ALAs antioxidant properties may help protect skin cells from UV damage, reduce inflammation, and support collagen integrity all key factors in skin aging

The resulting oxidative stress impairs mitochondrial respiration, compromises ETC function, and increases membrane permeability, resulting in reduced ATP production and potential mitochondrial shutdown [97, 98]

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