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Antiproliferative effects of isoalantolactone in human liver cancer cells are mediated through caspase-dependent apoptosis, ROS generation, suppression of cell migration and invasion and targeting Ras/Raf/MEK signalling pathway

Injecting more slowly and waiting before withdrawing the needle minimizes this issue

It delivers measurable systemic exposure rather than theoretical dose

Curcumin reduced symptoms of IBD in a small clinical trial and improved the relapse rate when used as an adjuvant therapy in another

doi: 10.1016/j.ijcard.2016.11.213

A well-known case is that of vitamin A, for which the administration of high doses in supplements has been associated with an increased risk of cancer