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TNFR1 binds to several proteins, including tumor necrosis factor receptor type 1associated death domain (TRADD), TNFR1-associated receptor-interacting protein kinase, also called receptor-interacting protein kinase (RIPK), and TNF receptor-associated factor 2 (TRAF2) [208]

According to an in vitro study, Piperine scavenged hydroxyl radical and was found to be a potent superoxide scavenger with an IC50 of 1.82 mM

Funding This research was supported by Key Research and Development Program of Shanxi Province (202302140601014), Postgraduate Practical Innovation Project 2024SJ266

One of the hallmarks of severe asthma is the depletion of antioxidant defences, including glutathione (GSH) and superoxide dismutase (SOD), both of which help neutralise reactive oxygen species (ROS)

In several cancer cell lines, including HT1080 and PANC1, the knockdown of NCOA4 prevents erastin-induced ferritin breakdown, iron buildup, and ferroptosis

Nature , 562(7728), 578-582