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This sympathetic overactivation triggers massive, inappropriate releases of stress hormones, including adrenaline and norepinephrine

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protein misfolding, mislocalization of TDP-43 to the cytoplasm, ER stress, inhibition of ER-Golgi transport, and apoptosis, in neuronal cells expressing pathological forms of TDP-43 or SOD1 (Parakh et al., 2020)

[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Kralj T., Kokot A., Zlatar M., Masnec S., Kasnik Kovac K., Milkovic Perisa M., Batelja Vuletic L., Giljanovic A., Strbe S., Sikiric S., et al

Furthermore, expression of WT, ALS-associated mutant, or truncated forms of TDP-43, promote CD14-mediated activation of microglia through NF-B signaling and NLRP3 inflammasomes (Zhao et al., 2015)