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It has been used: As part of the treatment for cyanide poisoning To dye tissues during surgery to determine tumors To relieve pain caused by oral mucositis To identify orthopedic injury to joint capsules To treat malaria before modern treatments were developed To treat encephalopathy, or confusion caused by chemotherapy Exploring other uses for methylene blue Earlier in my career, while working in emergency medicine, I read two papers that discussed using methylene blue as part of photodynamic therapy for lichen planus, a type of precancerous lesion in the mouth

Therefore, the clinical diagnosis is primarily one of exclusion, and the current illness must be distinguished both from other systemic inflammatory, rheumatic, malignant and infectious conditions, as well as the effects of co-morbid or pre-existing conditions (67, 68)

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High-throughput screening is feasible, and genetic complementation studies can be conducted

Route of administration documented in the protocol