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Med Sci Monitor (2019) 25:395

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Liproxstatin-1 maintains the integrity of the blood-spinal barrier by upregulating the expression of tight junction proteins and reduces ferroptosis in endothelial cells by upregulating GPX4 and downregulating ACSL4 and ALOX5

Epidithiodiketopiperazines inhibit protein degradation by targeting proteasome deubiquitinase Rpn11

Finally, to assess a functional indicator of oxidative damage and mitochondrial reactive oxygen species production, the activity of aconitase, a redox-sensitive enzyme in the tricarboxylic acid cycle, was measured