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In the Phase 2 paper there was no clear depression signal, but a letter to the editor in The Lancet noted that the trial excluded patients with psychiatric histories, which makes the safety estimate look better than it might be in a general population

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created an innovative dual-target c-MET/PD-1 antibody (BsAb) that blocks HGF-driven cell growth, movement, and apoptosis prevention, and prevents HGF-induced autophosphorylation at c-MET Tyr1234/1235 locations, protein kinase B (AKT), and extracellular signal-regulated kinases (ERK1/2)