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Bedaquiline does not induce or inhibit major CYP isoenzymes, namely, CYP1A2, CYP2C9, CYP2C19, or CYP2D6 at clinically relevant concentrations, minimizing the risk of CYP450-related interactions (Mesens et al., 2010)

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therefore, molecules that modulate kinase functions are expected to be promising new drugs

amide analogue (IF-3) the hydroxyl group in the compound of formula (XV-1b) may first be converted to an azide and then reduced to the corresponding amine

doi: 10.3389/fendo.2014.00082 58

FIGURE 10 In summary, for direct injection of bioactive factors, their limited in vivo persistence may necessitate frequent injections to maintain therapeutic efficacy