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PLoS ONE 14:e0217365

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Additionally, the interindividual variability in gut microbiota composition significantly influences polyphenol biotransformation into bioactive metabolites, complicating the prediction of therapeutic outcomes and impeding the standardization of treatments (Cardona et al

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Studies have shown that at doses high enough to fully saturate intestinal B12 receptors, oral B12 is effective, despite a lack of intrinsic factor