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The effector used by PERK to protect the ER from these peroxides might be NRF2, since it has been reported that PERK phosphorylates NRF2 at Ser40, thus preventing its degradation by KEAP1 [31]

Size-exclusion chromatography and SDS-PAGE analysis for final quality control are shown in (Extended Data Fig

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Future work should consider further the role of CBS polymerisation in protein misfolding and aggregation

Key antioxidant that stimulates the production and activity of white blood cells for immunity, and reduces oxidative stress