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As mitochondrial dysfunction is a major topic in this review, it is necessary to include some key recent progress in the discovery of defective mitophagy as a driver of neurodegeneration via accumulation of damaged mitochondria (PMID: 30742114

This paper adopts a relatively macro perspective as its approach for integration and elaboration

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TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members

Efferocytosis The cell-mediated engulfment and clearance of apoptotic cells, which is similar to phagocytosis