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Ethics declarations Ethics approval and consent to participate Animal studies and procedures were carried out in accordance with an approved protocol from the Institutional Animal Care and Use Committee (IACUC) at the Fourth Military Medical University (IACUC-20220505)

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In separate experiments, the cells were treated in the absence of the protein transport inhibitor and cell-free supernatants were analyzed for cytokine concentrations using a Bio-Plex Pro Human Cytokine 27-Plex Assay (Bio-Rad, Hercules, CA, USA, #M500KCAF0Y-S)

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Cirrhosis can be excluded with the APRI (AST-platelet ratio index) or FIB-4 tests, however both require a lab/hospital visit for venipuncture