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iScience 23 , 101503 (2020)

Abstract Currently, an increasing number of diseases related to insulin resistance and obesity is an alarming problem worldwide

L., Zenk, J., Kuskowski, M., Ward, L., & Bastian, E

On the one hand, patients will appreciate any small improvement gained from treatment, but on the other, they are usually in a mindset that makes them very vulnerable and causes then to have unrealistic expectations

As noted by Kraus et al., Nature Medicine and Ng et al., Journal of Endocrinology , targeting both systemic metabolism and localized fat cell activity may enhance fat-loss outcomes beyond either approach alone